Small GTP-binding protein, Rab6, is associated with secretory granules in atrial myocytes

Hiroshi Iida, Shigeyasu Tanaka, Yosaburo Shibata

研究成果: ジャーナルへの寄稿学術誌査読

22 被引用数 (Scopus)


Rab proteins, a subfamily of small GTP-binding proteins, have been shown to play key roles in regulation of vesicular traffic in eukaryotic cells. In this study, we have intended to identify the atrial granule-associated Rab proteins that seem to be required for formation or intracellular transport of the granules. Atrial granules contained at least four small GTP-binding proteins, and we have demonstrated by biochemical analysis that one of the small GTP-binding proteins associated with the atrial granules is a Rab6 protein (Rab6p). Rab6p was also detected in highly purified zymogen granules of pancreatic exocrine gland. Immunogold electron microscopy performed on ultrathin cryosections of rat auricle revealed that Rab6p was associated with the atrial granule membranes. Association of Rab6p with the atrial granule membranes was also confirmed by immunodiffusion electron microscopy in agarose-embedded atrial granules. These data indicate that Rab6p is associated with the atrial granules and that it might function in the intracellular traffic of the secretory granules in the atrial myocytes.

ジャーナルAmerican Journal of Physiology - Cell Physiology
5 41-5
出版ステータス出版済み - 1997

!!!All Science Journal Classification (ASJC) codes

  • 生理学
  • 細胞生物学


「Small GTP-binding protein, Rab6, is associated with secretory granules in atrial myocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。