Sister acts: Coordinating DNA replication and cohesion establishment

Rebecca Sherwood, Tatsuro S. Takahashi, Prasad V. Jallepalli

研究成果: ジャーナルへの寄稿総説査読

58 被引用数 (Scopus)

抄録

The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.

本文言語英語
ページ(範囲)2723-2731
ページ数9
ジャーナルGenes and Development
24
24
DOI
出版ステータス出版済み - 12月 15 2010
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 発生生物学

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