Significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy

Takao Ohtsuka, Kenji Kitahara, Satoru Matsuyama, Tomonori Shimonishi, Yuji Nakafusa, Kohji Miyazaki

研究成果: ジャーナルへの寄稿学術誌査読

10 被引用数 (Scopus)

抄録

Background/Aims: The significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy (PD) has not been well understood. The aim of this study was to clarify this issue. Methodology: Clinical records of 60 Japanese patients who underwent PD were reviewed retrospectively. Patients were divided into two groups, normal (n=33) and low (n=27) pancreatic exocrine function, according to the preoperative value of N-benzoyl-L-tyrosyl-p-aminobenzoic acid excretion test (normal value >70%). We compared the perioperative events and nutritional status between the two groups. Results: The preoperative and operative characteristics between the two groups were not significantly different. Postoperative pancreatic juice output from the remnant pancreas during the initial 7 days after PD was greater (1145±618 vs. 741±612mL, P=0.02), and the prevalence of pancreatic anastomotic leakage was higher (10/23, 30% vs. 1/27, 4%, P=0.008) in the group with normal pancreatic exocrine function than that in the insufficient group. Perioperative body mass index and serum albumin concentration, which reflect the nutritional status of patients, were significantly lower in the group with low pancreatic exocrine function (P=0.007 and 0.04, respectively). Conclusions: Surgeons should pay more attention to pancreatic anastomotic leakage in patients with normal pancreatic exocrine function after PD. On the other hand, in patients with insufficient exocrine function, perioperative nutritional support should be considered.

本文言語英語
ページ(範囲)788-791
ページ数4
ジャーナルHepato-gastroenterology
53
71
出版ステータス出版済み - 9月 2006
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 肝臓学
  • 消化器病学

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