Signals controlling the development and activity of regulatory B-lineage cells

Yoshihiro Baba, Masanori Matsumoto, Tomohiro Kurosaki

研究成果: ジャーナルへの寄稿学術誌査読

34 被引用数 (Scopus)

抄録

The fundamental concepts surrounding B cells with inhibitory function (regulatory B cells) are now being established. In the context of autoimmune and inflammatory animal models, B cells play an immunomodulatory role via IL-10 production and contribute to limitation of the pathogenesis. Recent studies have notably identified the human counterparts of these cells, which have been suggested to be relevant to the pathophysiology of disease. Clear criteria to identify these cell subsets and the key molecular mechanisms underlying their physiological features are required for understanding the big picture of regulatory B cells. Plasmablasts have recently been identified as a major IL-10-producing regulatory B-cell subset and Ca2+ signaling has furthermore been found to contribute to B-cell IL-10 expression. In this review, the signaling components controlling IL-10-dependent B-cell regulatory function and the development of IL-10-competent/-producing B cells and plasmablasts are discussed.

本文言語英語
ページ(範囲)487-493
ページ数7
ジャーナルInternational immunology
27
10
DOI
出版ステータス出版済み - 10月 2015
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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