SF-1/Ad4BP transforms primary long-term cultured bone marrow cells into ACTH-responsive steroidogenic cells

Shigeki Gondo, Toshihiko Yanase, Taijiro Okabe, Tomoko Tanaka, Hidetaka Morinaga, Masatoshi Nomura, Kiminobu Goto, Hajime Nawata

研究成果: ジャーナルへの寄稿学術誌査読

50 被引用数 (Scopus)

抄録

Bone marrow stem cells develop into haematopoietic and mesenchymal lineages, but have not been known to participate in steroidogenic cell production. Steroidogenic factor 1 (SF-1), also designated adrenal 4 binding protein (Ad4BP), is an essential orphan nuclear receptor for steroidogenesis as well as for adrenal and gonadal gland development. In the present study, we revealed that the adenovirus-mediated forced expression of SF-1 can transform cultured primary long-term cultured bone marrow cells into steroidogenic cells, showing the de novo synthesis of multiple steroid hormones in response to adrenocorticotropic hormone (ACTH). This finding may provide an initial step in innovative autograft cell transfer therapy for steroid hormone deficiencies.

本文言語英語
ページ(範囲)1239-1247
ページ数9
ジャーナルGenes to Cells
9
12
DOI
出版ステータス出版済み - 12月 2004

!!!All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 細胞生物学

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