Serum CC-10 in inflammatory lung diseases

Qing Ye, Masaki Fujita, Hiroshi Ouchi, Ichiro Inoshima, Takashige Maeyama, Kazuyoshi Kuwano, Yasuhiro Horiuchi, Nobuyuki Hara, Yoichi Nakanishi

研究成果: ジャーナルへの寄稿学術誌査読

35 被引用数 (Scopus)


Background: Although Clara cell secretory protein (CC-10) has been ascribed an anti-inflammatory role in lung diseases, its precise role remains unclear. Objective: To further our understanding of the role of CC-10 in inflammatory lung diseases, CC-10 protein levels were measured. Methods: Sera or bronchoalveolar lavage (BAL) fluids were collected from patients with different inflammatory lung diseases including bronchial asthma, chronic obstructive lung disease (COPD), sarcoidosis, idiopathic interstitial pneumonia (IIP), chronic eosinophilic pneumonia (CEP), pneumonia and lung cancer. Serum CC-10 concentrations were measured by enzyme-linked immunosorbent assay using urinary protein-1 antibody. Then, the relationships between CC-10 concentrations and lung diseases were investigated. Immunohistochemistry was performed using lung biopsy samples. Results: Increased serum CC-10 levels were recognized in IIP patients, while CC-10 levels were decreased in bronchial asthma patients and CEP patients. Immunohistochemistry revealed an aberrant expression in areas of fibrosis in IIP patients. Serum CC-10 concentrations were not associated with severity among IIP, COPD, and sarcoidosis. In contrast, serum CC-10 concentrations were correlated with FEV1/FVC in bronchial asthma patients. Conclusions: Although the number of patients was quite limited, these data provide new insights into the role of CC-10 in lung diseases, and the possibility that the CC-10 concentration in serum could be a new marker indicating the severity of bronchial asthma.

出版ステータス出版済み - 2004

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