Self-setting barrier membrane for guided tissue regeneration method: Initial evaluation of alginate membrane made with sodium alginate and calcium chloride aqueous solutions

Kunio Ishikawa, Yoshiya Ueyama, Takamitsu Mano, Takahiro Koyama, Kazuomi Suzuki, Tomohiro Matsumura

研究成果: ジャーナルへの寄稿学術誌査読

54 被引用数 (Scopus)

抄録

Alginate membrane was proposed as a self-setting barrier membrane that can be used for guided tissue regeneration (GTR). The alginate membrane can be prepared and placed at the bone defect during the surgical procedure. The procedure consists of two simple steps. First, the bone defect is filled with sodium alginate (Na-Alg) aqueous solution. Then calcium chloride aqueous solution is dropped on the surface of the Na-Alg aqueous solution. An alginate membrane is formed on the bone defect, keeping the inside of the bone defect filled with unreacted Na-Alg aqueous solution. In this investigation, a preliminary animal study was conducted for an initial evaluation as to whether or not the alginate membrane can be used as a barrier membrane for the GTR method. Bone defects were made in the tibiae of 15-week-old rats. The alginate membrane was made on the surface of existing bone by filling the defect with Na-Alg aqueous solution and then dropping calcium chloride aqueous solution onto the surface of the Na-Alg solution. Four weeks after surgery, the bone defect was found to be reconstructed with new bone when the defect had been covered with alginate membrane whereas the bone defect was filled only with connective tissue when it had been kept open. We concluded, therefore, that this alginate membrane may be a useful barrier membrane when the GTR method is employed.

本文言語英語
ページ(範囲)111-115
ページ数5
ジャーナルJournal of Biomedical Materials Research
47
2
DOI
出版ステータス出版済み - 1999
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生体材料
  • 生体医工学

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