Search of type 2 diabetes susceptibility gene on chromosome 20q

F. Takeuchi, K. Yanai, H. Inomata, N. Kuzuya, H. Kajio, S. Honjo, N. Takeda, Y. Kaburagi, K. Yasuda, S. Shirasawa, T. Sasazuki, N. Kato

研究成果: ジャーナルへの寄稿学術誌査読

14 被引用数 (Scopus)

抄録

Significant evidence of linkage to type 2 diabetes (T2D) has been shown in a relatively broad region on chromosome 20q, where the hepatocyte nuclear factor-4α (HNF4A) has been noted as a positional candidate. To systematically evaluate genetic susceptibility to T2D in the relevant region, we examined the disease association by using 1145 SNPs in two-step screening in the Japanese population. The marker screening enabled us to identify significant disease association in the lipopolysaccharide binding protein (LBP) but not in the HNF4A locus. In a 17.7-Mb interval screened, the strongest association was identified for a SNP, rs2232592, located in the intron of LBP, with an estimated odds ratio of 1.73 (95% CI 1.30-2.31) (P = 0.0002) in the whole study panel involving 675 case and 474 control subjects. Our data suggest that the LBP gene may confer genetic susceptibility to T2D and this warrants further replication study.

本文言語英語
ページ(範囲)1100-1106
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
357
4
DOI
出版ステータス出版済み - 6月 15 2007
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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