Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier

Teruaki Hasegawa; Tomohisa Fujisawa; Shuichi Haraguchi; Munenori Numata; Ryouji Karinaga; Taro Kimura; Shiro Okumura; Kazuo Sakurai; Seiji Shinkai

doi:10.1016/j.bmcl.2004.10.071

Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier

Teruaki Hasegawa
, Tomohisa Fujisawa
, Shuichi Haraguchi
, Munenori Numata
, Ryouji Karinaga
, Taro Kimura
, Shiro Okumura
, Kazuo Sakurai
, Seiji Shinkai

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

22 被引用数 (Scopus)

抄録

Schizophyllan having folate-appendages was synthesized from native schizophyllan through NaIO ₄-oxidation and the subsequent reductive amination in aqueous ammonia followed by amido-coupling with folic acid. The resulting folate-appended schizophyllan can form stable complex with poly(dA), show specific affinity toward folate binding protein, and mediate effective antisense activity in cancer cells.

本文言語	英語
ページ（範囲）	327-330
ページ数	4
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	15
号	2
DOI	https://doi.org/10.1016/j.bmcl.2004.10.071
出版ステータス	出版済み - 1月 17 2005
外部発表	はい

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!!!All Science Journal Classification (ASJC) codes

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

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title = "Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier",

abstract = "Schizophyllan having folate-appendages was synthesized from native schizophyllan through NaIO 4-oxidation and the subsequent reductive amination in aqueous ammonia followed by amido-coupling with folic acid. The resulting folate-appended schizophyllan can form stable complex with poly(dA), show specific affinity toward folate binding protein, and mediate effective antisense activity in cancer cells.",

author = "Teruaki Hasegawa and Tomohisa Fujisawa and Shuichi Haraguchi and Munenori Numata and Ryouji Karinaga and Taro Kimura and Shiro Okumura and Kazuo Sakurai and Seiji Shinkai",

note = "Funding Information: This work was supported by the Japan Science and Technology Corporation (SORST Program). We also thank Taito Co., Japan, for providing the native schizophyllan.",

year = "2005",

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doi = "10.1016/j.bmcl.2004.10.071",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier

AU - Hasegawa, Teruaki

AU - Fujisawa, Tomohisa

AU - Haraguchi, Shuichi

AU - Numata, Munenori

AU - Karinaga, Ryouji

AU - Kimura, Taro

AU - Okumura, Shiro

AU - Sakurai, Kazuo

AU - Shinkai, Seiji

N1 - Funding Information: This work was supported by the Japan Science and Technology Corporation (SORST Program). We also thank Taito Co., Japan, for providing the native schizophyllan.

PY - 2005/1/17

Y1 - 2005/1/17

N2 - Schizophyllan having folate-appendages was synthesized from native schizophyllan through NaIO 4-oxidation and the subsequent reductive amination in aqueous ammonia followed by amido-coupling with folic acid. The resulting folate-appended schizophyllan can form stable complex with poly(dA), show specific affinity toward folate binding protein, and mediate effective antisense activity in cancer cells.

AB - Schizophyllan having folate-appendages was synthesized from native schizophyllan through NaIO 4-oxidation and the subsequent reductive amination in aqueous ammonia followed by amido-coupling with folic acid. The resulting folate-appended schizophyllan can form stable complex with poly(dA), show specific affinity toward folate binding protein, and mediate effective antisense activity in cancer cells.

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UR - https://www.scopus.com/pages/publications/10644280698#tab=citedBy

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DO - 10.1016/j.bmcl.2004.10.071

M3 - Article

C2 - 15603948

AN - SCOPUS:10644280698

SN - 0960-894X

VL - 15

SP - 327

EP - 330

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier

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UN SDG

!!!All Science Journal Classification (ASJC) codes

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