Salivary glands in mikulicz’s disease

Masafumi Moriyama, Seiji Nakamura

研究成果: 書籍/レポート タイプへの寄稿

抄録

Mikulicz’s disease (MD) was considered to be a subtype of Sjögren’s syndrome (SS), based on histopathological similarities. However, recent studies have indicated that patients with MD show high serum IgG4 concentrations and suggested that MD is an “IgG4-related disease” and distinguishable from SS. We examined the clinical and serological features of MD and SS in detail to determine the ways in which the two conditions can be differentiated. MD can be diagnosed quickly and simply using diagnostic criteria such as serum IgG4 values and the presence of IgG4+ cells in the salivary glands, in conjunction with salivary gland imaging, sonography, and CT scans. Glucocorticoid therapy of MD reduces IgG and IgG4 levels and improves salivary function. A negative correlation between disease duration and increasing rate of salivary flow was observed in MD.

本文言語英語
ホスト出版物のタイトルIgg4-Related Disease
出版社Springer Japan
ページ85-92
ページ数8
ISBN(電子版)9784431542285
ISBN(印刷版)9784431542278
DOI
出版ステータス出版済み - 1月 1 2014

!!!All Science Journal Classification (ASJC) codes

  • 医学一般
  • 免疫学および微生物学一般

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