Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Shan Lu; Shinichi Nishimura; Go Hirai; Masashi Ito; Teppei Kawahara; Miho Izumikawa; Mikiko Sodeoka; Kazuo Shin-Ya; Toshio Tsuchida; Hideaki Kakeya

doi:10.1039/c5cc01953b

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Shan Lu
, Shinichi Nishimura
, Go Hirai
, Masashi Ito
, Teppei Kawahara
, Miho Izumikawa
, Mikiko Sodeoka
, Kazuo Shin-Ya
, Toshio Tsuchida
, Hideaki Kakeya

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

24 被引用数 (Scopus)

抄録

Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp³ carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

本文言語	英語
ページ（範囲）	8074-8077
ページ数	4
ジャーナル	Chemical Communications
巻	51
号	38
DOI	https://doi.org/10.1039/c5cc01953b
出版ステータス	出版済み - 5月 11 2015
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

電子材料、光学材料、および磁性材料
触媒
セラミックおよび複合材料
化学一般
表面、皮膜および薄膜
金属および合金
材料化学

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title = "Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.",

abstract = "Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp3 carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.",

author = "Shan Lu and Shinichi Nishimura and Go Hirai and Masashi Ito and Teppei Kawahara and Miho Izumikawa and Mikiko Sodeoka and Kazuo Shin-Ya and Toshio Tsuchida and Hideaki Kakeya",

note = "Publisher Copyright: {\textcopyright} 2015 The Royal Society of Chemistry.",

year = "2015",

month = may,

day = "11",

doi = "10.1039/c5cc01953b",

language = "English",

volume = "51",

pages = "8074--8077",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "38",

}

TY - JOUR

T1 - Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

AU - Lu, Shan

AU - Nishimura, Shinichi

AU - Hirai, Go

AU - Ito, Masashi

AU - Kawahara, Teppei

AU - Izumikawa, Miho

AU - Sodeoka, Mikiko

AU - Shin-Ya, Kazuo

AU - Tsuchida, Toshio

AU - Kakeya, Hideaki

PY - 2015/5/11

Y1 - 2015/5/11

N2 - Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp3 carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

AB - Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp3 carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

UR - https://www.scopus.com/pages/publications/84928963034

UR - https://www.scopus.com/pages/publications/84928963034#tab=citedBy

U2 - 10.1039/c5cc01953b

DO - 10.1039/c5cc01953b

M3 - Article

C2 - 25869768

AN - SCOPUS:84928963034

SN - 1359-7345

VL - 51

SP - 8074

EP - 8077

JO - Chemical Communications

JF - Chemical Communications

IS - 38

ER -

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

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!!!All Science Journal Classification (ASJC) codes

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