Role of inducible nitric oxide synthase in rostral ventrolateral medulla in blood pressure regulation in spontaneously hypertensive rats

Yoshikuni Kimura, Yoshitaka Hirooka, Takuya Kishi, Koji Ito, Yoji Sagara, Kenji Sunagawa

研究成果: ジャーナルへの寄稿学術誌査読

20 被引用数 (Scopus)

抄録

Nitric oxide (NO) in the brainstem modulates blood pressure (BP). Overexpression of inducible NO synthase (iNOS) in the rostral ventrolateral medulla (RVLM) increases BP in normotensive Wistar-Kyoto rats (WKY), but its role in BP regulation in spontaneously hypertensive rats (SHR) is unknown. We examined iNOS expression and the effect of iNOS inhibitors in the RVLM on BP and heart rate in SHR and WKY. iNOS levels in the RVLM were significantly higher in SHR than in WKY. Bilateral microinjection of aminoguanidine into the RVLM dose-dependently decreased BP and heart rate in SHR, but not in WKY. These findings suggest that iNOS expression in the RVLM of SHR contributes to increase BP.

本文言語英語
ページ(範囲)281-286
ページ数6
ジャーナルClinical and Experimental Hypertension
31
3
DOI
出版ステータス出版済み - 5月 2009
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 内科学
  • 生理学

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