Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory

Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

研究成果: ジャーナルへの寄稿学術誌査読

7 被引用数 (Scopus)

抄録

Heterozygous rolling Nagoya (rol/+) mice with a CaV2.1α1 mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5μg/side) or CaV2.1 inhibitor levetiracetam (0.1μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.

本文言語英語
ページ(範囲)353-356
ページ数4
ジャーナルBehavioural Brain Research
218
2
DOI
出版ステータス出版済み - 4月 15 2011
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 行動神経科学

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