TY - JOUR
T1 - Rheumatic fever-mimicking carditis as a first presentation of chronic active Epstein-Barr virus infection
AU - Toubo, Taikai
AU - Ohga, Shouichi
AU - Takada, Hidetoshi
AU - Suga, Naohiro
AU - Nomura, Akihiko
AU - Ohno, Takurou
AU - Hara, Toshiro
PY - 2006/5
Y1 - 2006/5
N2 - A 7-y-old girl presented with prolonged fever, arrhythmia and cardiomegaly during the treatment course of group A β-haemolytic streptococcal pharyngitis. The isolated rheumatogenic strain M1 suggested the diagnosis of rheumatic fever. However, serous pericardial effusion contained high levels of Epstein-Barr virus (EBV) DNA. Clonally proliferating EBV+ T cells were determined in the circulation. The atypical carditis without valvitis was then complicated by coronary artery dilatations. Four months after the start of prednisolone plus antiviral/bacterial therapy, EBV+ T-cell lymphoma developed in the thigh. Conclusion: Atypical carditis may be a notable and life-threatening presentation of chronic active EBV infection to be differentiated from rheumatic fever.
AB - A 7-y-old girl presented with prolonged fever, arrhythmia and cardiomegaly during the treatment course of group A β-haemolytic streptococcal pharyngitis. The isolated rheumatogenic strain M1 suggested the diagnosis of rheumatic fever. However, serous pericardial effusion contained high levels of Epstein-Barr virus (EBV) DNA. Clonally proliferating EBV+ T cells were determined in the circulation. The atypical carditis without valvitis was then complicated by coronary artery dilatations. Four months after the start of prednisolone plus antiviral/bacterial therapy, EBV+ T-cell lymphoma developed in the thigh. Conclusion: Atypical carditis may be a notable and life-threatening presentation of chronic active EBV infection to be differentiated from rheumatic fever.
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U2 - 10.1080/08035250500371821
DO - 10.1080/08035250500371821
M3 - Article
C2 - 16825143
AN - SCOPUS:33646897396
SN - 0803-5253
VL - 95
SP - 614
EP - 618
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
IS - 5
ER -