RhCl3-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

Mieko Arisawa; Manabu Kuwajima; Atsushi Suwa; Masahiko Yamaguchi

doi:10.3987/COM-09-S(S)110

RhCl₃-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

Mieko Arisawa
, Manabu Kuwajima
, Atsushi Suwa
, Masahiko Yamaguchi

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

10 被引用数 (Scopus)

抄録

RhCl₃ catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.

本文言語	英語
ページ（範囲）	1239-1248
ページ数	10
ジャーナル	Heterocycles
巻	80
号	2
DOI	https://doi.org/10.3987/COM-09-S(S)110
出版ステータス	出版済み - 3月 1 2010
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

分析化学
薬理学
有機化学

文献へのアクセス

10.3987/COM-09-S(S)110

他のファイルとリンク

引用スタイル

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title = "RhCl3-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid",

abstract = "RhCl3 catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.",

keywords = "A7/B7 Disulfide, Catalysis, Disulfide Exchange Reaction, Insulin, Rhodium Chloride",

author = "Mieko Arisawa and Manabu Kuwajima and Atsushi Suwa and Masahiko Yamaguchi",

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T1 - RhCl3-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

AU - Arisawa, Mieko

AU - Kuwajima, Manabu

AU - Suwa, Atsushi

AU - Yamaguchi, Masahiko

PY - 2010/3/1

Y1 - 2010/3/1

N2 - RhCl3 catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.

AB - RhCl3 catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.

KW - A7/B7 Disulfide

KW - Catalysis

KW - Disulfide Exchange Reaction

KW - Insulin

KW - Rhodium Chloride

UR - https://www.scopus.com/pages/publications/77955691323

UR - https://www.scopus.com/pages/publications/77955691323#tab=citedBy

U2 - 10.3987/COM-09-S(S)110

DO - 10.3987/COM-09-S(S)110

M3 - Article

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SN - 0385-5414

VL - 80

SP - 1239

EP - 1248

JO - Heterocycles

JF - Heterocycles

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