Retinoblastoma in children of advanced age

Purpose: To report 3 children who developed retinoblastoma with atypical clinical manifestations at the age of 8 years each. Cases: All the 3 cases were girls and were unilaterally affected. One case had hyperemia of affected eye as chief complaint. Her left eye simulated uveitis with visual acuity of 1.5. The other 2 cases showed vitreous opacity or hemorrhage with visual acuity of hand motion. Diagnostic imaging showed no intraocular tumor or calcification in all the cases. Enucleation led to the diagnosis of retinoblastoma with vitreous dissemination in the 3 cases. There has been no recurrence or metastasis during the follow-up for 16 months, 4 years and 7 years respectively. Conclusion: The present cases illustrate that retinoblastoma in children of advanced age may show atypical clinical manifestations. This particular feature needs due attention.