Reserved Sertoli cell function in the hypogonadic male patients with myotonic dystrophy.

X. Y. Lou, Y. Nishi, M. Haji, Y. Antoku, S. Tanaka, S. Ikuyama, T. Yanase, R. Takayanagi, H. Nawata

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

To clarify the Sertoli cell and Leydig cell function in hypogonadic male patients with myotonic dystrophy (DM), serum concentrations of inhibin, total testosterone (TT), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were measured by radioimmunoassay in 6 male DM patients (41 to 56 years old, 47.7 +/- 5.05 years old) and compared with those in normal adult men. In 116 healthy men aged from 24 to 92 years, serum inhibin and TT levels decreased and serum FSH and LH concentrations increased with advancing age. There was an inverse correlation between serum inhibin and FSH. These results support the concept of negative feedback regulation system of FSH secretion by inhibin. Male DM patients showed significantly lower serum TT and higher concentrations of FSH and LH, compared with the age-matched 39 normal adult men (49-59 years old, 48.2 +/- 6.14 years old). However, there was no significant difference in serum inhibin levels between the patients and normal counterparts. These results indicate that the Sertoli cell function is reserved in male DM patient, although the Leydig cell function is impaired. It is also suggested that in these patients a negative feedback control system between inhibin and FSH may be disordered to some extent.

本文言語英語
ページ(範囲)168-174
ページ数7
ジャーナルFukuoka igaku zasshi = Hukuoka acta medica
85
5
出版ステータス出版済み - 5月 1994
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 医学一般

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