TY - JOUR
T1 - Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells
AU - Yasukochi, Atsushi
AU - Kawakubo-Yasukochi, Tomoyo
AU - Morioka, Masahiko
AU - Hazekawa, Mai
AU - Nishinakagawa, Takuya
AU - Ono, Kazuhiko
AU - Nakashima, Manabu
AU - Nakamura, Seiji
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Collagen type XVII (COL17) is expressed in various tissues and its aberrant expression is associated with tumour progression. In this study, we investigated the regulation of COL17 expression in oral squamous cell carcinoma (OSCC) using the cell lines NA, SAS, Ca9-22, and Sa3. COL17 was induced upon p53 activation by cisplatin in SAS; however, this effect was more limited in NA and hardly in Ca9-22 and Sa3, with mutated p53. Moreover, COL17 was found to be regulated by miR203a-3p in all cell lines. Our data suggest that COL17 expression in OSCC cell lines is regulated by p53 and miR203a-3p.
AB - Collagen type XVII (COL17) is expressed in various tissues and its aberrant expression is associated with tumour progression. In this study, we investigated the regulation of COL17 expression in oral squamous cell carcinoma (OSCC) using the cell lines NA, SAS, Ca9-22, and Sa3. COL17 was induced upon p53 activation by cisplatin in SAS; however, this effect was more limited in NA and hardly in Ca9-22 and Sa3, with mutated p53. Moreover, COL17 was found to be regulated by miR203a-3p in all cell lines. Our data suggest that COL17 expression in OSCC cell lines is regulated by p53 and miR203a-3p.
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U2 - 10.1093/jb/mvz024
DO - 10.1093/jb/mvz024
M3 - Article
C2 - 30918974
SN - 0021-924X
VL - 166
SP - 163
EP - 173
JO - Journal of biochemistry
JF - Journal of biochemistry
IS - 2
ER -