TY - JOUR
T1 - Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED)
T2 - a promising new treatment in pediatric surgery
AU - Taguchi, Tomoaki
AU - Yanagi, Yusuke
AU - Yoshimaru, Koichiro
AU - Zhang, Xiu Ying
AU - Matsuura, Toshiharu
AU - Nakayama, Koichi
AU - Kobayashi, Eiji
AU - Yamaza, Haruyoshi
AU - Nonaka, Kazuaki
AU - Ohga, Shouichi
AU - Yamaza, Takayoshi
N1 - Publisher Copyright:
© 2019, Springer Nature Singapore Pte Ltd.
PY - 2019/4/10
Y1 - 2019/4/10
N2 - Stem cells from human exfoliated deciduous teeth (SHEDs), being a type of mesenchymal stem cell, are an ideal cell source for regenerative medicine. They have minimal risk of oncogenesis, high proliferative capacity, high multipotency, and immunosuppressive ability. Stem cell transplantation using SHED has been found to have an anti-fibrotic effect on liver fibrosis in mice. SHED transplantation and the bio 3D printer, which can create scaffold-free 3-D images of the liver and diaphragm, provide a new innovative treatment modality for intractable pediatric surgical diseases such as biliary atresia and diaphragmatic hernia.
AB - Stem cells from human exfoliated deciduous teeth (SHEDs), being a type of mesenchymal stem cell, are an ideal cell source for regenerative medicine. They have minimal risk of oncogenesis, high proliferative capacity, high multipotency, and immunosuppressive ability. Stem cell transplantation using SHED has been found to have an anti-fibrotic effect on liver fibrosis in mice. SHED transplantation and the bio 3D printer, which can create scaffold-free 3-D images of the liver and diaphragm, provide a new innovative treatment modality for intractable pediatric surgical diseases such as biliary atresia and diaphragmatic hernia.
UR - http://www.scopus.com/inward/record.url?scp=85062709903&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062709903&partnerID=8YFLogxK
U2 - 10.1007/s00595-019-01783-z
DO - 10.1007/s00595-019-01783-z
M3 - Review article
C2 - 30834983
AN - SCOPUS:85062709903
SN - 0941-1291
VL - 49
SP - 316
EP - 322
JO - Surgery today
JF - Surgery today
IS - 4
ER -
