TY - JOUR
T1 - Refractive error is associated with intracranial volume
AU - Takeuchi, Hikaru
AU - Taki, Yasuyuki
AU - Nouchi, Rui
AU - Yokoyama, Ryoichi
AU - Kotozaki, Yuka
AU - Nakagawa, Seishu
AU - Sekiguchi, Atsushi
AU - Iizuka, Kunio
AU - Yamamoto, Yuki
AU - Hanawa, Sugiko
AU - Araki, Tsuyoshi
AU - Miyauchi, Carlos Makoto
AU - Shinada, Takamitsu
AU - Sakaki, Kohei
AU - Sassa, Yuko
AU - Nozawa, Takayuki
AU - Ikeda, Shigeyuki
AU - Yokota, Susumu
AU - Daniele, Magistro
AU - Kawashima, Ryuta
N1 - Funding Information:
We respectfully thank Yuki Yamada for operating the MRI scanner, and Haruka Nouchi for being an examiner of psychological tests. We also thank study participants, the other examiners of psychological tests, and all of our colleagues in Institute of Development, Aging and Cancer and in Tohoku University for their support. This study was supported by a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306) and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology. The authors would like to thank Enago (www.enago.jp) for the English language review.
Publisher Copyright:
© 2017 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Myopia is part of the spectrum of refractive error. Myopia is associated with psychometric intelligence and, the link between brain anatomy and myopia has been hypothesized. Here we aimed to identify the associations between brain structures and refractive error in developed young adults. In a study cohort of 1,319 normal educated young adults, the refractive error showed a significant negative correlation with total intracranial volume and total cerebrospinal fluid (CSF) volume but not with total gray matter volume (GMV) or total white matter volume (WMV). Time spent studying was associated with refractive error but could not explain the aforementioned associations with brain volume parameters. The R2 values of the simple regression between spherical equivalent and outcome variables for each sex in non-whole brain imaging analyses were less than 0.05 in all cases and thus were weak. Psychometric intelligence was not associated with refractive error or total CSF volume, but it weakly positively correlated with total GMV and total WMV in this study population. Thus, refractive error appears to be primarily (weakly) associated with the volume of the cranium, whereas psychometric intelligence was associated with the volume of the brain.
AB - Myopia is part of the spectrum of refractive error. Myopia is associated with psychometric intelligence and, the link between brain anatomy and myopia has been hypothesized. Here we aimed to identify the associations between brain structures and refractive error in developed young adults. In a study cohort of 1,319 normal educated young adults, the refractive error showed a significant negative correlation with total intracranial volume and total cerebrospinal fluid (CSF) volume but not with total gray matter volume (GMV) or total white matter volume (WMV). Time spent studying was associated with refractive error but could not explain the aforementioned associations with brain volume parameters. The R2 values of the simple regression between spherical equivalent and outcome variables for each sex in non-whole brain imaging analyses were less than 0.05 in all cases and thus were weak. Psychometric intelligence was not associated with refractive error or total CSF volume, but it weakly positively correlated with total GMV and total WMV in this study population. Thus, refractive error appears to be primarily (weakly) associated with the volume of the cranium, whereas psychometric intelligence was associated with the volume of the brain.
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U2 - 10.1038/s41598-017-18669-0
DO - 10.1038/s41598-017-18669-0
M3 - Article
C2 - 29317746
AN - SCOPUS:85040527786
SN - 2045-2322
VL - 8
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 175
ER -