Radiotherapy for early-stage primary ocular adnexal mucosa-associated lymphoid tissue lymphoma

Saiji Ohga, Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Tadamasa Yoshitake, Kazushige Atsumi, Kotaro Terashima, Kaori Asai, Keiji Matsumoto, Hiroshi Yoshikawa, Yo Ichi Kawano, Hiroshi Honda

研究成果: ジャーナルへの寄稿学術誌査読

18 被引用数 (Scopus)


Background: Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (POAML) is a rare disease. The purpose of this study was to evaluate the treatment outcome and patterns of failure of patients with early-stage POAML treated with radiotherapy. Patients and Methods: From 1995 to 2008, 53 patients with early-stage POAML were reviewed. Tumors were categorized as either superficial or mass-forming type. In principle, superficial lesions (n=11) were treated with 24 Gy, while the mass-forming lesions (n=42) were irradiated with 30 Gy. The median follow-up period was 3.9 years. Results: All four cases of relapse had mass-forming lesions. The 5-year overall and progression-free survival rates were 100% and 91.5%, respectively. Although 30 patients experienced grade 2 or 3 late adverse events, no patients had radiation-related retinopathy. Conclusion: Early-stage POAML can be well-controlled with radiotherapy. However, the risk of distant relapse should be noted, in particular, for mass-forming tumors.

ジャーナルAnticancer research
出版ステータス出版済み - 12月 2013

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究


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