Radiation-induced osteosarcoma with a rhabdomyosarcoma component arising from the dura mater: A case report

S. Utsuki, H. Oka, K. Sato, S. Shimizu, S. Suzuki, K. Fujii

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

Objective: Radiation-induced tumors are a rare complication of radiation therapy. Here, we describe the first case of a radiation-induced osteosarcoma with a rhabdomyosarcoma component arising from the dura mater after radiation therapy for an astrocytoma. Patient: An 18-year-old man with generalized seizures presented with a neoplastic lesion in the dura mater of a previously irradiated (56 Gy) region 5 years after the initial radiation therapy. A tumor resection was performed, and histological examination revealed an osteosarcoma with a rhabdomyosarcoma component. The tumor recurred despite eight tumorectomies and the addition of chemotherapy and radiotherapy. The patient died from tumor progression 5 years after the first surgical removal of the radiation-induced tumor. Conclusion: This radiation-induced tumor may have originated from primitive, multipotent mesenchymal cells, as it included both osteosarcoma and rhabdomyosarcoma components.

本文言語英語
ページ(範囲)96-100
ページ数5
ジャーナルClinical Neuropathology
28
2
DOI
出版ステータス出版済み - 2009

!!!All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 神経学
  • 臨床神経学

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