Radar chart deviation analysis of prion protein amino acid composition defines characteristic structural abnormalities of the N-terminal octapeptide tandem repeat

Satoru Yokotani, Takeru Nose, Yuji Horiuchi, Ayami Matsushima, Yasuyuki Shimohigashi

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

Analysis of the amino acid composition of prion protein using a newly developed program for radar-chart deviation analysis has identified an abnormality or irregularity of the N-terminal flexible domain. Aromatic amino acids Trp and His together with Gly are abnormally abounding in this Nterminal domain, in which octapeptide GQPHGGGW is connected four times in tandem. This tetrarepeat structure has been suggested to be essential for the prion protein not only to play an intrinsic functional role in the physiological condition, but also to bring on structural abnormalities in prion disease.

本文言語英語
ページ(範囲)949-955
ページ数7
ジャーナルProtein and Peptide Letters
15
9
DOI
出版ステータス出版済み - 9月 2008

!!!All Science Journal Classification (ASJC) codes

  • 構造生物学
  • 生化学

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