Pretreatment with R(+)-8-OH-DPAT, a selective serotonin (5-HT)(1A) receptor agonist (50 μg/kg, s.c.), inhibited D-amphetamine sulfate (1.0 mg/kg, s.c.)-induced increases in extracellular levels of both 5-HT and dopamine (DA) in rat medial prefrontal cortex, as determined by in vivo microdialysis. The inhibitory effect of R(+)-8-OH-DPAT was completely reversed by the selective 5-HT(1A) receptor antagonist WAY 100,635 (100 μg/kg s.c.) administered 5 min prior to R(+)-8-OH-DPAT. These results suggest that stimulation of 5-HT(1A) receptors may inhibit amphetamine-induced release of 5-HT and DA in the medial prefrontal cortex.
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