Prognostic factors in ovarian carcinosarcoma: A clinicopathological and immunohistochemical analysis of 23 cases

K. Ariyoshi, S. Kawauchi, T. Kaku, H. Nakano, M. Tsuneyoshi

研究成果: ジャーナルへの寄稿学術誌査読

63 被引用数 (Scopus)

抄録

Carcinosarcoma of the ovary is a rare, highly aggressive neoplasm comprising histologically of both epithelial and mesenchymal components. The aim of this study was to evaluate the clinicopathological prognostic factors in ovarian carcinosarcoma, including the immunohistochemical expression of p53 protein and Ki67. Methods and results: Twenty-three cases of carcinosarcoma of the ovary were studied retrospectively. The clinicopathological and immunohistochemical parameters including p53 and Ki67 staining were statistically analysed to investigate the prognostic significance of this tumour. The overall 5-year survival rate was 27.1%; 100% for stage I, 31.3% for stage II, 10.9% for stage III and 0% for stage IV. The low-stage group (stages I and II) was found to be a significant prognostic factor for patient survival (P = 0.0113). None of the other factors (tumour size, histological type of carcinomatous and sarcomatous components, mitotic count, vascular space invasion and immunoreactivity for p53 protein and Ki67) was found to be a statistically significant prognostic indicator. Conclusions: Ovarian carcinosarcoma is a rare malignancy with poor prognosis. In this study, advanced stage appears to be poor prognostic indicator of survival in patients with ovarian carcinosarcoma.

本文言語英語
ページ(範囲)427-436
ページ数10
ジャーナルHistopathology
37
5
DOI
出版ステータス出版済み - 2000

!!!All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 組織学

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