Profiles of Sex Hormones and Sex Hormone-Binding Globulin in Men with Impaired Glucose Tolerance and Non-Insulin Dependent Diabetes Mellitus

The purpose of this study was to investigate the profiles of sex hormone and sex hormone-binding globulin (SHBG) levels in Japanese men with impaired glucose tolerance (IGT) and those with non -insulin-dependent diabetes mellitus (NIDDM). After matching for age, some obesity indices and physical fitnesss levels, sex hormone, LH, FSH and SHBG levels in the two groups were compared. There were no siginificant differences between the groups. However, free testosterone and SHBG levels in the IGT and NIDDM groups were significantly lower than those of the control group. From these results in men, it is suggested that relative hypogonadism may exist in patients with the early phase of NIDDM and/or IGT.