Pro-senescent effect of hydrogen peroxide on cancer cells and its possible application to tumor suppression

Kaichi Yoshizaki, Tsukasa Fujiki, Takahiro Tsunematsu, Makiko Yamashita, Miyako Udono, Sanetaka Shirahata, Yoshinori Katakura

研究成果: ジャーナルへの寄稿学術誌査読

8 被引用数 (Scopus)


Mild oxidative stress is known to induce premature senescence, termed stress-induced premature senescence (SIPS), in normal human diploid cells. We investigated to determine whether mild oxidative stress would trigger SIPS in a human tumor cell line, human lung adenocarcinoma A549. The results showed that sublethal concentrations of H2O2 induced SIPS in A549 cells and consequently attenuated, but did not completely eliminate, the tumorigenicity of these cells. We next investigated the reasons for this incomplete impairment of tumorigenicity in A549 cells in SIPS. The results suggested that H2O2-treated A549 cells are composed of a heterogeneous cell population: one is sensitive to H2O2, and the other is resistant or undergoes reversal; the latter reverted to their original tumorigenic form. The molecular mechanisms determining the cellular fate of tumor cells in SIPS should be identified in order to make use of SIPS and oncogene-induced senescence in tumor cells as methods of tumor suppression.

ジャーナルBioscience, Biotechnology and Biochemistry
出版ステータス出版済み - 2009

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学


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