Principles and development of collagen-mediated tissue fusion induced by laser irradiation

Shun Sasaki, Tetsuo Ikeda, Shin ichiro Okihara, Shotaro Nishimura, Ryu Nakadate, Hiroshi Saeki, Eiji Oki, Masaki Mori, Makoto Hashizume, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿学術誌査読

7 被引用数 (Scopus)


The mechanism underlying tissue fusion mediated by laser irradiation remains unclear. We clarify the mechanisms underlying laser-mediated tissue fusion using a novel model. Microscopic examinations of morphological changes within the adventitia of a bovine carotid artery and a collagen sheet prepared from bovine dermis showed collagen fibril bundle loosening and collagen fibre swelling following heating at 46 °C. An incised bovine carotid artery covered with a collagen sheet to which pressure and laser heat of 40 °C–52 °C were applied created a structure that was pressure resistant to >300 mmHg. Microscopic analyses of the irradiation site showed collagen fibril interdigitation. Hence, low-temperature laser-mediated tissue fusion causes collagen fibril bundles to loosen and swell, and crimping causes the fibres to intertwine. As the temperature declines, the loosened and swollen fibrils and fibres tighten, and collagen fibre interdigitation is completed. This technology could be applied to fuse tissues during surgery.

ジャーナルScientific reports
出版ステータス出版済み - 12月 1 2019

!!!All Science Journal Classification (ASJC) codes

  • 一般


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