Preparation of artificial glycolipids and their aggregation behavior in aqueous media

Yoshio Hisaeda; Eiji Ohshima; Jun Ichi Kikuchi; Yukito Murakami

doi:10.1016/S0040-4039(97)01572-4

Preparation of artificial glycolipids and their aggregation behavior in aqueous media

Yoshio Hisaeda, Eiji Ohshima, Jun Ichi Kikuchi, Yukito Murakami

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

4 被引用数 (Scopus)

抄録

N,N-Dihexadecyl-N(α)-[6-(β-D-galactopyranosyl)hexanoyl]-L-alaninamide and N,N- dihexadecyl-N(α)-[6{(β-D-galactopyranosyl)-(1→4)-O-(D -glucopyranosyl)}hexanoyl]-L-alaninamide, which have an amino acid residue interposed between a polar sugar moiety and a hydrophobic double-chain segment individually, were prepared and characterized as novel artificial glycolipids. Morphological studies by means of differential scanning calorimetry and dynamic light scattering as well as electron microscopy clarified that these lipids tend to form stable bilayer membranes by themselves in aqueous media.

本文言語	英語
ページ（範囲）	6713-6716
ページ数	4
ジャーナル	Tetrahedron Letters
巻	38
号	38
DOI	https://doi.org/10.1016/S0040-4039(97)01572-4
出版ステータス	出版済み - 9月 22 1997

!!!All Science Journal Classification (ASJC) codes

生化学
創薬
有機化学

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10.1016/S0040-4039(97)01572-4

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@article{e352078ad4dd41d1a700d3626b2c2748,

title = "Preparation of artificial glycolipids and their aggregation behavior in aqueous media",

abstract = "N,N-Dihexadecyl-N(α)-[6-(β-D-galactopyranosyl)hexanoyl]-L-alaninamide and N,N- dihexadecyl-N(α)-[6{(β-D-galactopyranosyl)-(1→4)-O-(D -glucopyranosyl)}hexanoyl]-L-alaninamide, which have an amino acid residue interposed between a polar sugar moiety and a hydrophobic double-chain segment individually, were prepared and characterized as novel artificial glycolipids. Morphological studies by means of differential scanning calorimetry and dynamic light scattering as well as electron microscopy clarified that these lipids tend to form stable bilayer membranes by themselves in aqueous media.",

author = "Yoshio Hisaeda and Eiji Ohshima and Kikuchi, {Jun Ichi} and Yukito Murakami",

note = "Funding Information: This work was supported in part by a Grant-in Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan and from the Ministry of Agriculture, Forestry and Fisheries in the framework of the Pioneering Research Project in Biotechnology.",

year = "1997",

month = sep,

day = "22",

doi = "10.1016/S0040-4039(97)01572-4",

language = "English",

volume = "38",

pages = "6713--6716",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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TY - JOUR

T1 - Preparation of artificial glycolipids and their aggregation behavior in aqueous media

AU - Hisaeda, Yoshio

AU - Ohshima, Eiji

AU - Kikuchi, Jun Ichi

AU - Murakami, Yukito

N1 - Funding Information: This work was supported in part by a Grant-in Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan and from the Ministry of Agriculture, Forestry and Fisheries in the framework of the Pioneering Research Project in Biotechnology.

PY - 1997/9/22

Y1 - 1997/9/22

N2 - N,N-Dihexadecyl-N(α)-[6-(β-D-galactopyranosyl)hexanoyl]-L-alaninamide and N,N- dihexadecyl-N(α)-[6{(β-D-galactopyranosyl)-(1→4)-O-(D -glucopyranosyl)}hexanoyl]-L-alaninamide, which have an amino acid residue interposed between a polar sugar moiety and a hydrophobic double-chain segment individually, were prepared and characterized as novel artificial glycolipids. Morphological studies by means of differential scanning calorimetry and dynamic light scattering as well as electron microscopy clarified that these lipids tend to form stable bilayer membranes by themselves in aqueous media.

AB - N,N-Dihexadecyl-N(α)-[6-(β-D-galactopyranosyl)hexanoyl]-L-alaninamide and N,N- dihexadecyl-N(α)-[6{(β-D-galactopyranosyl)-(1→4)-O-(D -glucopyranosyl)}hexanoyl]-L-alaninamide, which have an amino acid residue interposed between a polar sugar moiety and a hydrophobic double-chain segment individually, were prepared and characterized as novel artificial glycolipids. Morphological studies by means of differential scanning calorimetry and dynamic light scattering as well as electron microscopy clarified that these lipids tend to form stable bilayer membranes by themselves in aqueous media.

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U2 - 10.1016/S0040-4039(97)01572-4

DO - 10.1016/S0040-4039(97)01572-4

M3 - Article

AN - SCOPUS:0030866361

SN - 0040-4039

VL - 38

SP - 6713

EP - 6716

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 38

ER -

Preparation of artificial glycolipids and their aggregation behavior in aqueous media

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!!!All Science Journal Classification (ASJC) codes

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