Preimplantation-embryo-specific cell cycle regulation is attributed to the low expression level of retinoblastoma protein

Naoki Iwamori, Kunihiko Naito, Koji Sugiura, Hideaki Tojo

研究成果: ジャーナルへの寄稿学術誌査読

26 被引用数 (Scopus)

抄録

It is known that a characteristic of the mammalian preimplantation-embryo-specific cell cycle is the substantially shortened G1-phase, although the regulation mechanisms of the unique cell cycle remain unclear. In the present study, we first examined the presence of retinoblastoma (RB) tumor suppressor gene product throughout mouse preimplantation embryo development and found that the RB expression was down-regulated between the four-cell and morula stages. Furthermore, the overexpression of RB protein in the mouse embryos during this phase inhibited their development significantly. These results suggest that the absence of RB protein contributes to the preimplantation-embryo-specific cell cycle.

本文言語英語
ページ(範囲)119-123
ページ数5
ジャーナルFEBS Letters
526
1-3
DOI
出版ステータス出版済み - 8月 28 2002
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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