Potentiation by a sodium channel activator of effects of lithium ion on cyclic AMP, cyclic GMP and inositol phosphates

S. Kanba, G. Yagi, T. Nakaki, R. Kato, E. Richelson

研究成果: ジャーナルへの寄稿学術誌査読

16 被引用数 (Scopus)

抄録

The effects of the lithium ion (Li+ ) on receptor-mediated synthesis of second messengers were determined, when cellular sodium channels were quiescent or excited, using the murine neuroblastoma clone (N1E-115). In this clone, lithium inhibited the receptor-mediated synthesis of cyclic AMP and cyclic GMP and it also increased the accumulation of inositol phosphates by a receptor-mediated process. When veratridine (20 μM) excited the sodium channel, the effects of lithium were potentiated. However, tetrodotoxin, a sodium channel blocker, completely prevented this potentiation. These results suggest that when neurons are depolarizing actively and intraneuronal levels of lithium increase by entry through the sodium channel, lithium has a more potent intracellular effect. As a result, lithium would have more potent and selective effects in those pathologically-active neurons underlying manic-depressive disorder.

本文言語英語
ページ(範囲)497-500
ページ数4
ジャーナルNeuropharmacology
30
5
DOI
出版ステータス出版済み - 5月 1991
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 細胞および分子神経科学

フィンガープリント

「Potentiation by a sodium channel activator of effects of lithium ion on cyclic AMP, cyclic GMP and inositol phosphates」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル