Potential pathways in the pathogenesis of IgG4-related disease

Masafumi Moriyama, Seiji Nakamura

研究成果: 書籍/レポート タイプへの寄稿

1 被引用数 (Scopus)

抄録

IgG4-related disease (IgG4-RD) is a systemic disease characterized by elevated serum IgG4 and a marked infiltration of IgG4-positive plasma cells into affected organs. Regarding the immunological aspects of this disease, it is well known that IgG4 is induced by T helper type 2 (Th2) cytokines such as interleukin (IL)-4 and IL-13. Thus, IgG4-RD is considered to be a Th2-predominant disease. In addition, innate immune cells have recently received increasing attention with regards to the initiation of IgG4-RD. Exploring the mechanism of innate and acquired immunity in IgG4-RD is a highly promising field of investigation. In this chapter, we focus on the selective localization and functions of individual Th subsets and innate immune cells to clarify the contribution of these cells to the pathogenesis of IgG4-RD.

本文言語英語
ホスト出版物のタイトルIgG4-Related Kidney Disease
出版社Springer Japan
ページ43-54
ページ数12
ISBN(電子版)9784431556879
ISBN(印刷版)9784431556862
DOI
出版ステータス出版済み - 1月 1 2016

!!!All Science Journal Classification (ASJC) codes

  • 医学一般
  • 免疫学および微生物学一般

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