Platelet decrease and efficacy of platelet-rich plasma return following peripheral blood stem cell apheresis

Takahiro Shima, Teppei Sakoda, Tomoko Henzan, Yuya Kunisaki, Takeshi Sugio, Kenjiro Kamezaki, Hiromi Iwasaki, Takanori Teshima, Takahiro Maeda, Koichi Akashi, Toshihiro Miyamoto

研究成果: ジャーナルへの寄稿学術誌査読


Background: Peripheral blood stem cell (PBSC) transplantation is a key treatment option for hematological diseases and is widely performed in clinical practice. Platelet loss is one of the major complications of PBSC apheresis, and platelet-rich plasma (PRP) return is considered in case of platelet decrease following apheresis; however, little is known about the frequency and severity of platelet loss and the efficacy of PRP return postapheresis. Methods: We assessed changes in platelet counts following PBSC-related apheresis in 270 allogeneic (allo)- and 105 autologous (auto)-PBSC settings. We also evaluated the efficacy of PRP transfusion on platelet recovery postapheresis. Results: In both allo- and auto-PBSC settings, the preapheresis platelet count (range, 84-385 and 33-558 × 109/L, respectively) decreased postapheresis (range, 57-292 and 20-429 × 109/L, respectively), whereas severe platelet decrease (<50 × 109/L) was only observed in auto-PBSC patients (n = 9). We confirmed that platelet count before apheresis was a risk factor for severe platelet decrease (<50 × 109/L) following auto-PBSC apheresis (odds ratio 0.749, P <.049). PRP return postapheresis facilitated platelet recovery in more than 80% of cases in both allo and auto settings. Conclusion: Lower platelet count preapheresis is a useful predictor of severe platelet decrease following auto-PBSC apheresis and PRP return is an effective process to facilitate platelet recovery postapheresis.

ジャーナルJournal of Clinical Apheresis
出版ステータス出版済み - 10月 2021

!!!All Science Journal Classification (ASJC) codes

  • 血液学


「Platelet decrease and efficacy of platelet-rich plasma return following peripheral blood stem cell apheresis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。