TY - JOUR
T1 - Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion
AU - Matsuda, Taito
AU - Irie, Takashi
AU - Katsurabayashi, Shutaro
AU - Hayashi, Yoshinori
AU - Nagai, Tatsuya
AU - Hamazaki, Nobuhiko
AU - Adefuin, Aliya Mari D.
AU - Miura, Fumihito
AU - Ito, Takashi
AU - Kimura, Hiroshi
AU - Shirahige, Katsuhiko
AU - Takeda, Tadayuki
AU - Iwasaki, Katsunori
AU - Imamura, Takuya
AU - Nakashima, Kinichi
N1 - Funding Information:
This work was supported by Grant-in-Aid for Research Activity Start-Up 15H06474 (to T.M.), Grant-in-Aid for JSPS Fellows 16J06261 (to T.M.), Grant-in-Aid for Young Scientists (B) 18K14820 (to T.M.), a Hayashi grant-in-aid for basic medical research ( Kyushu University ) (to K.N.), Grant-in-Aid for Scientific Research on Innovative Areas 16H06527 (to K.N.), and the Platform Project for Supporting Drug Discovery and Life Science Research ( Basis for Supporting Innovative Drug Discovery and Life Science Research [BINDS]) from the Japan Agency for Medical Research and Development (AMED) under grants JP16am0101102 , JP16am0101103 , and JP16am0101105 . We thank Dr. K.F. Tanaka for sharing the FUW-Iba1-M2rtTA vector; Dr. K. Inoue for sharing BV2 cells; Y. Nakagawa for excellent secretarial assistance; I. Smith for proofreading the manuscript; Dr. F. D. Costantini for sharing Rosa-YFP reporter mice; Dr. K. Hayashi and Dr. G. Nagamatsu for technical help; L. Cong, S. Yeung, P. Singh, and A. Rymar (Plexxikon) for providing PLX5622; I. Goto (EPS EKISHIN) for providing the PLX5622-formulated diet; and Dr. K. Sawamoto for valuable comments and support of this project. We appreciate technical assistance from the Research Support Center, Research Center for Human Disease Modeling, Kyushu University Graduate School of Medical Sciences.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/2/6
Y1 - 2019/2/6
N2 - Matsuda et al. report direct neuronal conversion of microglia induced by the expression of a single transcription factor, NeuroD1, which occupies bivalent epigenetic domains for neuronal gene induction. NeuroD1 can also converts microglia into neurons in the adult mouse striatum.
AB - Matsuda et al. report direct neuronal conversion of microglia induced by the expression of a single transcription factor, NeuroD1, which occupies bivalent epigenetic domains for neuronal gene induction. NeuroD1 can also converts microglia into neurons in the adult mouse striatum.
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U2 - 10.1016/j.neuron.2018.12.010
DO - 10.1016/j.neuron.2018.12.010
M3 - Article
C2 - 30638745
AN - SCOPUS:85060776529
SN - 0896-6273
VL - 101
SP - 472-485.e7
JO - Neuron
JF - Neuron
IS - 3
ER -