Pinacidil inhibits the ryanodine‐sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein

Zhiling Xiong; Shunichi Kajioka; Takeshi Sakai; Kenji Kitamura; Hirosi Kuriyama

doi:10.1111/j.1476-5381.1991.tb12252.x

Pinacidil inhibits the ryanodine‐sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein

Zhiling Xiong
, Shunichi Kajioka
, Takeshi Sakai
, Kenji Kitamura
, Hirosi Kuriyama

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

21 被引用数 (Scopus)

抄録

Pinacidil, a potassium‐channel opener, inhibited the ryanodine‐sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP‐sensitive K‐channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist. 1991 British Pharmacological Society

本文言語	英語
ページ（範囲）	788-790
ページ数	3
ジャーナル	British Journal of Pharmacology
巻	102
号	4
DOI	https://doi.org/10.1111/j.1476-5381.1991.tb12252.x
出版ステータス	出版済み - 4月 1991
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

薬理学

文献へのアクセス

10.1111/j.1476-5381.1991.tb12252.x

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引用スタイル

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AU - Kuriyama, Hirosi

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KW - glibenclamide

KW - intracellular Ca store sites

KW - oscillatory outward current

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