TY - JOUR
T1 - Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application
AU - Katsuda, Takeshi
AU - Ikeda, Shingo
AU - Yoshioka, Yusuke
AU - Kosaka, Nobuyoshi
AU - Kawamata, Masaki
AU - Ochiya, Takahiro
N1 - Funding Information:
Acknowledgments: This work was supported in part by a Grant-in-Aid for the Third-Term Comprehensive 10-Year Strategy for Cancer Control; a Grant-in-Aid for Scientific Research on Priority Areas Cancer from the Ministry of Education, Culture, Sports, Science and Technology; the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NiBio); the Japan Society for the Promotion of Science (JSPS) through the ‘Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program)’, initiated by the Council for Science and Technology Policy (CSTP); a Grant-in-Aid for Scientific Research on Innovative Areas (‘functional machinery for non-coding RNAs’) from the Japanese Ministry of Education, Culture, Sports, Science, and Technology; and the Comprehensive Research and Development of a Surgical Instrument for Early Detection and Rapid Curing of Cancer Project (P10003) of the New Energy and Industrial Technology Development Organization (NEDO).
PY - 2014/4/1
Y1 - 2014/4/1
N2 - MicroRNAs (miRNAs) have attracted significant attention because of their important roles in a variety of physiological and pathological processes. Recent studies have shown that many cell types secrete miRNAs by packaging them into lipid-bilayered small vesicles called exosomes. Furthermore, exosomal miRNAs travel between cells, exert their RNAi effects in the recipient cells, and play important roles in various biological processes. In this article, we will summarize and describe the latest studies on exosomal miRNAs by focusing on their roles in cancer progression, immune regulation, and tissue repair. We will also provide a perspective on the clinical applications of this research field.
AB - MicroRNAs (miRNAs) have attracted significant attention because of their important roles in a variety of physiological and pathological processes. Recent studies have shown that many cell types secrete miRNAs by packaging them into lipid-bilayered small vesicles called exosomes. Furthermore, exosomal miRNAs travel between cells, exert their RNAi effects in the recipient cells, and play important roles in various biological processes. In this article, we will summarize and describe the latest studies on exosomal miRNAs by focusing on their roles in cancer progression, immune regulation, and tissue repair. We will also provide a perspective on the clinical applications of this research field.
UR - https://www.scopus.com/pages/publications/84896754362
UR - https://www.scopus.com/pages/publications/84896754362#tab=citedBy
U2 - 10.1515/hsz-2013-0222
DO - 10.1515/hsz-2013-0222
M3 - Review article
C2 - 24323889
AN - SCOPUS:84896754362
SN - 1431-6730
VL - 395
SP - 365
EP - 373
JO - Biological Chemistry
JF - Biological Chemistry
IS - 4
ER -
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