Photochemical generation of C4′-oxidized abasic site containing oligodeoxynucleotide and its efficient amine modification

Mariko Aso, Kazuteru Usui, Mitsuhiro Fukuda, Yoshie Kakihara, Tsuyoshi Goromaru, Hiroshi Suemune

研究成果: ジャーナルへの寄稿学術誌査読

23 被引用数 (Scopus)

抄録

We synthesized oligodeoxynucleotide (ODN, 3), which contains 4′-o-nitrobenzyloxythymidine (4) as a caged precursor of C4′-oxidized abasic site (1). Photoirradiation of 3 at 365 nm followed by amine treatment under neutral conditions afforded the lactam (2) efficiently. Duplexed ODN 3 was converted to 1 faster and more efficiently than single stranded 3, whereas amine treatment of 1 formed from single stranded 3 resulted in slightly faster lactam formation than with the duplex.

本文言語英語
ページ(範囲)3183-3186
ページ数4
ジャーナルOrganic letters
8
15
DOI
出版ステータス出版済み - 7月 20 2006

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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