Pharmacokinetic profiles of 3-(4-hydroxy-3-methoxyphenyl) propionic acid and its conjugates in Sprague-Dawley rats

Chizumi Abe, Ayano Soma, Tint Ni Ni Tun, Ye Zhang, Yosuke Nishitani, Hiroyuki Kayaki, Hideaki Kawakami, Toshiro Matsui

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

3-(4-hydroxy-3-methoxyphenyl)propionic acid (HMPA) is one of the end-products from gut microbiota from dietary polyphenols, which might contribute to their health benefits. This study aims to investigate the absorption, metabolism, and tissue accumulation of HMPA in Sprague-Dawley (SD) rats. After HMPA (10 mg/kg body weight) was orally administered, intact and conjugated HMPAs in the bloodstream were detected and reached the maximum concentration in 15 min (HMPA, 2.6 ± 0.4 nmol/mL; sulfated HMPA, 3.6 ± 0.9 nmol/mL; glucuronidated HMPA, 0.55 ± 0.09 nmol/mL). HMPA and its conjugates were also detected in the target organs 6 h postadministration, indicating that HMPA undergoes rapid conversion into conjugates, and they broadly distribute to organs with similar profiles (kidneys > liver > thoracic aorta > heart > soleus muscle > lungs). This study demonstrated that orally administered HMPA (10 mg/kg) in SD rats undergoes rapid metabolism and wide tissue distribution with ≥1.2% absorption ratio.

本文言語英語
ページ(範囲)516-524
ページ数9
ジャーナルBioscience, Biotechnology and Biochemistry
87
5
DOI
出版ステータス出版済み - 5月 1 2023

!!!All Science Journal Classification (ASJC) codes

  • 医学一般

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