PBPK-CFD hybrid approach for estimating airway tissue dosimetry: Development of Computer Simulated Person with numerical respiratory tract model-part3

The effects of air pollution found in indoors and prevention of exposure to hazardous chemical compounds are an important issue in the interest of public health. In this research, Computer Simulated Person (CSP) that integrated thermo-regulation and numerical respiratory tract model was developed for applying comprehensive assessment of health risk caused by indoor environmental quality problem. This paper (Part 3) treats the development of integrated numerical simulation method of Physiologically Based Pharmaco-Kinetic (PBPK) model and Computational Fluid Dynamics (CFD) for estimating respiratory tract tissue dosimetry. The PBPK-CFD model was incorporated into numerical airway mode that integrated into CSP. Here, inhalation exposure and its health impact were analyzed by using PBPK-CFD-CSP model under the indoor environmental condition of formaldehyde emitted from building materials.