Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries

Morihide Mitoma, Takahiko Oho, Naoko Michibata, Kaoru Okano, Yutaka Nakano, Masataka Fukuyama, Toshihiko Koga

研究成果: ジャーナルへの寄稿学術誌査読

22 被引用数 (Scopus)

抄録

Cell surface protein antigen (PAc) and glucosyltransferases (GTF) of Streptococcus mutans are major colonization factors of the organism. We prepared bovine milk containing antibodies against a fusion of the saliva-binding alanine-rich region of PAc with the glucan-binding domain of GTF-I. This study examined the effect of the immune milk on the cariogenicity of S. mutans in a rat model. Concentrated immune milk was fed to rats once a day for 55 days. The group that received immune milk had significantly less caries development than controls.

本文言語英語
ページ(範囲)2721-2724
ページ数4
ジャーナルInfection and Immunity
70
5
DOI
出版ステータス出版済み - 2002

!!!All Science Journal Classification (ASJC) codes

  • 寄生虫科
  • 微生物学
  • 免疫学
  • 感染症

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