TY - CHAP
T1 - Pannexin 3, a gap junction protein, regulates chondrocyte differentiation in part through hemichannel activity
AU - Iwamoto, Tsutomu
AU - Ono, Mariko
AU - Arakaki, Makiko
AU - Nakamura, Takashi
AU - Yamada, Aya
AU - Fukumoto, Satoshi
N1 - Publisher Copyright:
© Springer 2012.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Gap junctional communications play a crucial role for organogenesis including cartilage development. Pannexin 3 (Panx3) belongs to the new member of the gap junction pannexin family. However, the expression and function of Panx3 have not been cleared. Here, we demonstrate that Panx3 is expressed in cartridge, and regulates chondrocyte differentiation in vitro cell culture. Our observations indicate that Panx3 plays a crucial role for the differentiation of chondrocyte, and suggest that Panx3 is a key molecule for cartilage development.
AB - Gap junctional communications play a crucial role for organogenesis including cartilage development. Pannexin 3 (Panx3) belongs to the new member of the gap junction pannexin family. However, the expression and function of Panx3 have not been cleared. Here, we demonstrate that Panx3 is expressed in cartridge, and regulates chondrocyte differentiation in vitro cell culture. Our observations indicate that Panx3 plays a crucial role for the differentiation of chondrocyte, and suggest that Panx3 is a key molecule for cartilage development.
UR - http://www.scopus.com/inward/record.url?scp=84957031872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957031872&partnerID=8YFLogxK
U2 - 10.1007/978-4-431-54070-0_100
DO - 10.1007/978-4-431-54070-0_100
M3 - Chapter
AN - SCOPUS:84957031872
SN - 9784431540694
SP - 346
EP - 348
BT - Interface Oral Health Science 2011
PB - Springer Japan
ER -