p62 bodies: cytosolic zoning by phase separation

Reo Kurusu, Hideaki Morishita, Masaaki Komatsu

研究成果: ジャーナルへの寄稿総説査読

3 被引用数 (Scopus)

抄録

Cellular zoning or partitioning is critical in preventing macromolecules from random diffusion and orchestrating the spatiotemporal dynamics of biochemical reactions. Along with membranous organelles, membraneless organelles contribute to the precise regulation of biochemical reactions inside cells. In response to environmental cues, membraneless organelles rapidly form through liquid–liquid phase separation, sequester certain proteins and RNAs, mediate specific reactions and dissociate. Among membraneless organelles, ubiquitin-positive condensates, namely, p62 bodies, maintain cellular homeostasis through selective autophagy of themselves to contribute to intracellular quality control. p62 bodies also activate the anti-oxidative stress response regulated by the KEAP1-NRF2 system. In this review, we present an overview of recent advancements in cellular and molecular biology related to p62 bodies, highlighting their dynamic nature and functions.

本文言語英語
ページ(範囲)141-146
ページ数6
ジャーナルJournal of biochemistry
175
2
DOI
出版ステータス出版済み - 2月 1 2024
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 医学一般

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