TY - JOUR
T1 - p62 bodies
T2 - cytosolic zoning by phase separation
AU - Kurusu, Reo
AU - Morishita, Hideaki
AU - Komatsu, Masaaki
N1 - Publisher Copyright:
© 2024 Oxford University Press. All rights reserved.
PY - 2024/2/1
Y1 - 2024/2/1
N2 - Cellular zoning or partitioning is critical in preventing macromolecules from random diffusion and orchestrating the spatiotemporal dynamics of biochemical reactions. Along with membranous organelles, membraneless organelles contribute to the precise regulation of biochemical reactions inside cells. In response to environmental cues, membraneless organelles rapidly form through liquid–liquid phase separation, sequester certain proteins and RNAs, mediate specific reactions and dissociate. Among membraneless organelles, ubiquitin-positive condensates, namely, p62 bodies, maintain cellular homeostasis through selective autophagy of themselves to contribute to intracellular quality control. p62 bodies also activate the anti-oxidative stress response regulated by the KEAP1-NRF2 system. In this review, we present an overview of recent advancements in cellular and molecular biology related to p62 bodies, highlighting their dynamic nature and functions.
AB - Cellular zoning or partitioning is critical in preventing macromolecules from random diffusion and orchestrating the spatiotemporal dynamics of biochemical reactions. Along with membranous organelles, membraneless organelles contribute to the precise regulation of biochemical reactions inside cells. In response to environmental cues, membraneless organelles rapidly form through liquid–liquid phase separation, sequester certain proteins and RNAs, mediate specific reactions and dissociate. Among membraneless organelles, ubiquitin-positive condensates, namely, p62 bodies, maintain cellular homeostasis through selective autophagy of themselves to contribute to intracellular quality control. p62 bodies also activate the anti-oxidative stress response regulated by the KEAP1-NRF2 system. In this review, we present an overview of recent advancements in cellular and molecular biology related to p62 bodies, highlighting their dynamic nature and functions.
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U2 - 10.1093/jb/mvad089
DO - 10.1093/jb/mvad089
M3 - Review article
C2 - 37948628
AN - SCOPUS:85185343069
SN - 0021-924X
VL - 175
SP - 141
EP - 146
JO - Journal of biochemistry
JF - Journal of biochemistry
IS - 2
ER -