Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation

Seiji Nakamura, Akiko Hiroki, Masanori Shinohara, Hisashi Gondo, Yukiko Ohyama, Takefumi Mouri, Masanori Sasaki, Kanemitsu Shirasuna, Mine Harada, Yoshiyuki Niho

研究成果: ジャーナルへの寄稿学術誌査読

69 被引用数 (Scopus)

抄録

We examined 37 patients who had undergone an allogeneic bone marrow transplantation and compared their oral findings to their systemic involvement with chronic graft-versus-host disease. Among the clinical signs and symptoms in their oral region, only the presence of oral lichenoid lesions had a statistically significant relationship to the diagnosis of chronic graft-versus-host disease. The histologic findings in the labial salivary glands and buccal mucosa closely reflected the status of chronic graft-versus-host disease. Statistically, the presence of diffuse and periductal lymphocytic infiltration in labial salivary glands, subepithelial lymphocytic infiltration and epithelial changes in buccal mucosa also showed a significant relationship to the diagnosis of chronic graft-versus-host disease. The present study suggests that a systematic oral examination, especially pathologic examination of the labial salivary glands and buccal mucosa, is useful in evaluating the status of chronic graft-versus-host disease.

本文言語英語
ページ(範囲)556-563
ページ数8
ジャーナルOral surgery, oral medicine, oral pathology, oral radiology, and endodontics
82
5
DOI
出版ステータス出版済み - 1996

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 口腔外科
  • 耳鼻咽喉科学
  • 歯学一般

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