Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning

Jun Yokose, Naoki Yamamoto, Sachie K. Ogawa, Takashi Kitamura

研究成果: ジャーナルへの寄稿学術誌査読

抄録

A critical feature of episodic memory formation is to associate temporally segregated events as an episode, called temporal association learning. The medial entorhinal cortical-hippocampal (EC-HPC) networks is essential for temporal association learning. We have previously demonstrated that pyramidal cells in the medial EC (MEC) layer III project to the hippocampal CA1 pyramidal cells and are necessary for trace fear conditioning (TFC), which is an associative learning between tone and aversive shock with the temporal gap. On the other hand, Island cells in MECII, project to GABAergic neurons in hippocampal CA1, suppress the MECIII input into the CA1 pyramidal cells through the feed-forward inhibition, and inhibit TFC. However, it remains unknown about how Island cells activity is regulated during TFC. In this study, we report that dopamine D1 receptor is preferentially expressed in Island cells in the MEC. Optogenetic activation of dopamine D1 receptors in Island cells facilitate the Island cell activity and inhibited hippocampal CA1 pyramidal cell activity during TFC. The optogenetic activation caused the impairment of TFC memory recall without affecting contextual fear memory recall. These results suggest that dopamine D1 receptor in Island cells have a crucial role for the regulation of temporal association learning.

本文言語英語
論文番号78
ジャーナルMolecular Brain
16
1
DOI
出版ステータス出版済み - 12月 2023
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 細胞および分子神経科学

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