TY - GEN
T1 - On-chip cell transportation based on vibration-induced local flow in open chip environment
AU - Hayakawa, Takeshi
AU - Sakuma, Shinya
AU - Arai, Fumihito
N1 - Publisher Copyright:
© 2015 IEEE.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2015/12/11
Y1 - 2015/12/11
N2 - We present a novel cell manipulation method based on vibration-induced flow in open-chip environment. By applying circular vibration to a chip having micropillar patterns on its surface, local whirling flow is induced around the micropillars. Therefore, by patterning micropillar array on a chip and applying the circular vibration to the chip, we can achieve cell transportation along the array in an open chip environment. We theoretically analyzed this phenomenon with a single micropillar, and experimentally evaluated behaviours of manipulated microbeads with two micropillars. We confirm there are different manipulation modes according to the pitch of micropillars. We designed the micropillar array for an oocyte transportation based on these evaluations. We succeeded in the transportation of oocytes with up to 35.6 μm/s and confirmed that the velocity can be changed by changing the frequency and amplitude of the applied vibration.
AB - We present a novel cell manipulation method based on vibration-induced flow in open-chip environment. By applying circular vibration to a chip having micropillar patterns on its surface, local whirling flow is induced around the micropillars. Therefore, by patterning micropillar array on a chip and applying the circular vibration to the chip, we can achieve cell transportation along the array in an open chip environment. We theoretically analyzed this phenomenon with a single micropillar, and experimentally evaluated behaviours of manipulated microbeads with two micropillars. We confirm there are different manipulation modes according to the pitch of micropillars. We designed the micropillar array for an oocyte transportation based on these evaluations. We succeeded in the transportation of oocytes with up to 35.6 μm/s and confirmed that the velocity can be changed by changing the frequency and amplitude of the applied vibration.
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U2 - 10.1109/IROS.2015.7353552
DO - 10.1109/IROS.2015.7353552
M3 - Conference contribution
AN - SCOPUS:84958174454
T3 - IEEE International Conference on Intelligent Robots and Systems
SP - 1409
EP - 1414
BT - IROS Hamburg 2015 - Conference Digest
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - IEEE/RSJ International Conference on Intelligent Robots and Systems, IROS 2015
Y2 - 28 September 2015 through 2 October 2015
ER -