Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles

Chalermchai Khemtong, Chase W. Kessinger, Osamu Togao, Jimin Ren, Masaya Takahashi, A. Dean Sherry, Jinming Gao

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

4 被引用数 (Scopus)

抄録

An off-resonance saturation (ORS) method was used for magnetic resonance imaging of superparamagnetic polymeric micelles (SPPM). SPPM was produced by encapsulating a cluster of magnetite nanoparticles (9.9±0.4 nm in diameter) in poly(ethylene glycol)-b-poly(D,L-lactide) (PEGPLA) copolymer micelles (micelle diameter: 60±9 nm). In ORS MRI, a selective radiofrequency (RF) pulse was applied at an off-resonance position (0-50 ppm) from the bulk water signal, and the SPPM particles were visualized by the contrast on a division image constructed from two images acquired with and without pre-saturation. Here, the effects of saturation offset frequencies, saturation durations, and RF powers on ORS contrasts were investigated as these parameters are critical for optimization of ORS MRI for in vivo imaging applications. The ability to turn "ON" and "OFF" ORS contrast of SPPM solutions permits for an accurate image subtraction and a contrast enhancement to visualize SPPM probes for in vivo imaging of cancer.

本文言語英語
ホスト出版物のタイトルProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
ホスト出版物のサブタイトルEngineering the Future of Biomedicine, EMBC 2009
出版社IEEE Computer Society
ページ4095-4097
ページ数3
ISBN(印刷版)9781424432967
DOI
出版ステータス出版済み - 2009
外部発表はい
イベント31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, 米国
継続期間: 9月 2 20099月 6 2009

出版物シリーズ

名前Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

その他

その他31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
国/地域米国
CityMinneapolis, MN
Period9/2/099/6/09

!!!All Science Journal Classification (ASJC) codes

  • 細胞生物学
  • 発生生物学
  • 生体医工学
  • 医学一般

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