Occipital lobe gray matter volume in male patients with chronic schizophrenia: A quantitative MRI study

Toshiaki Onitsuka, Robert W. McCarley, Noriomi Kuroki, Chandlee C. Dickey, Marek Kubicki, Susan S. Demeo, Melissa Frumin, Ron Kikinis, Ferenc A. Jolesz, Martha E. Shenton

研究成果: ジャーナルへの寄稿学術誌査読

70 被引用数 (Scopus)

抄録

Schizophrenia is characterized by deficits in cognition as well as visual perception. There have, however, been few magnetic resonance imaging (MRI) studies of the occipital lobe as an anatomically defined region of interest in schizophrenia. To examine whether or not patients with chronic schizophrenia show occipital lobe volume abnormalities, we measured gray matter volumes for both the primary visual area (PVA) and the visual association areas (VAA) using MRI based neuroanatomical landmarks and three-dimensional information. PVA and VAA gray matter volumes were measured using high-spatial resolution MRI in 25 male patients diagnosed with chronic schizophrenia and in 28 male normal controls. Chronic schizophrenia patients showed reduced bilateral VAA gray matter volume (11%), compared with normal controls, whereas patients showed no group difference in PVA gray matter volume. These results suggest that reduced bilateral VAA may be a neurobiological substrate of some of the deficits observed in early visual processing in schizophrenia.

本文言語英語
ページ(範囲)197-206
ページ数10
ジャーナルSchizophrenia research
92
1-3
DOI
出版ステータス出版済み - 5月 2007

!!!All Science Journal Classification (ASJC) codes

  • 精神医学および精神衛生
  • 生物学的精神医学

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