In this paper, the four-roll plate bending process of 2.25Cr- 1Mo-0.25V steel at elevated temperature is investigated by numerical simulation. This 3-D simulation is finished by using the elastic-plastic dynamic explicit finite element method (FEM) under the ANSYS/LS-DYNA environment. The strain softening behavior of 2.25Cr-1Mo-0.25V steel at elevated temperature is presented and discussed. The stress-strain relationship of the steel plate is modeled using a piecewise linear material model, with the stress-strain curve obtained through tensile tests. The plate bending process with a plate thickness of 150 mm is investigated. The amount and position of maximum plastic deformation are analyzed. The present study provides an important basis for the optimization of bending parameters and further investigation of the effect of high-Temperature deformation on the resistance to hydrogen attack of 2.25Cr-1Mo-0.25V steel.