Nuclear expression of the Y-box binding protein, YB-1, as a novel marker of disease progression in non-small cell lung cancer

Kotaro Shibahara, Takeshi Uchiumi, Michihiko Kuwano, Yoshihiko Maehara, Kenji Sugio, Toshihiro Osaki, Kosei Yasumoto, Kimitoshi Kohno

研究成果: ジャーナルへの寄稿学術誌査読

167 被引用数 (Scopus)

抄録

Transcription factor Y-box binding protein 1 (YB-1) that binds to the inverted CCAAT box is involved not only in transcription of various genes but also in cell proliferation and DNA repair. We determined whether localization of YB-1 in either the nucleus or cytoplasm could serve as a prognostic marker for patients with non-small cell lung cancer (NSCLC). In 196 NSCLC patients, expression of YB-1 protein in the nucleus or cytoplasm was immunohistochemically evaluated. Of the 196 tumors examined, 88 (44.9%) were positive for YB-1 expression in the nucleus. Nuclear YB-1 expression significantly correlated with T factor, lymph node metastasis, and stage of the disease. Patients with a nuclear YB-1 tumor had a poorer prognosis than did those with a cytoplasmic YB-1 tumor in all of the NSCLC patients (P=0.0494) and in patients with squamous cell carcinoma (P=0.0313) but not in patients with adenocarcinomas. Nuclear localization of the YB-1 protein may prove to be an important factor of disease progression for patients with NSCLC, in particular, in cases of squamous cell carcinoma.

本文言語英語
ページ(範囲)3151-3155
ページ数5
ジャーナルClinical Cancer Research
7
10
出版ステータス出版済み - 2001

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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