Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia

Eriko Nagasawa, Yasunobu Abe, Takamitsu Matsushima, Ilseung Choi, Yoshimichi Tachikawa, Rie Ohtsuka, Hideki Ishikura, Junji Nishimura, Shoichi Inaba, Hajime Nawata, Koichiro Muta

研究成果: ジャーナルへの寄稿学術誌査読

抄録

We describe a 70-year-old woman with acute myelogenous leukemia with t(8;21) in the first relapse who underwent nonmyeloablative transplantation with conditioning of fludarabine and low-dose total body irradiation (2Gy). Myelosuppression was very mild, and the patient developed transient grade I renal and hepatic toxicities. Complete chimerism was achieved on day 120. The level of the AML1/MTG8 fusion gene in bone marrow decreased to an undetectable level on day 56 and the patient is alive and in complete remission with a follow-up at day 450. This transplant regimen might be well tolerated even by the elderly patients and bring a durable remission.

本文言語英語
ページ(範囲)167-169
ページ数3
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
45
2
出版ステータス出版済み - 2月 2004
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 医学一般

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